Decreased single-photon emission computed tomographic {123I}β-CIT striatal uptake correlates with symptom severity in parkinson's disease

Authors

  • Dr J. P. Seibyl MD,

    Corresponding author
    1. Departments of Diagnostic Radiology, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    2. Departments of Psychiatry, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    • Section of Neuclear Medicine, TF-2, Department of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208042, New Haven, CT 06520-8042
    Search for more papers by this author
  • K. L. Marchek MD,

    1. Departments of Neurology, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    Search for more papers by this author
  • D. Quinlan PhD,

    1. Departments of Psychiatry, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    Search for more papers by this author
  • K. Sheff MD, PhD,

    1. Departments of Psychiatry, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    Search for more papers by this author
  • S. Zoghbi PhD,

    1. Departments of Diagnostic Radiology, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    Search for more papers by this author
  • Y. Zea-Ponce PhD,

    1. Departments of Psychiatry, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    Search for more papers by this author
  • R. M. Baldwin PhD,

    1. Departments of Psychiatry, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    Search for more papers by this author
  • B. Fussell BS,

    1. Departments of Neurology, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    Search for more papers by this author
  • E. O. Smith BS,

    1. Departments of Diagnostic Radiology, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    Search for more papers by this author
  • D. S. Charney MD,

    1. Departments of Psychiatry, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    Search for more papers by this author
  • P. B. Hoffer MD,

    1. Departments of Diagnostic Radiology, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    Search for more papers by this author
  • R. B. Innis MD, PhD

    1. Departments of Psychiatry, Yale University School of Medicine, New Haven, and West Haven Veterans Affairs Medical Center, West Haven, CT
    Search for more papers by this author

Abstract

Previous studies have utilized single-photon emission computed tomography (SPECT) to demonstrate decreased {123I}β-CIT striatal uptake in idiopathic Parkinson disease (PD) patients. The present study extendss this work by examining SPECT outcome measures in a larger group of PD patients with varying disease severity. Twenty-eight l-dopa-responsive PD patients (Hoehn-Yahr stages 1–4) and 27 healthy controls had SPECT scans at 18 to 24 hours after injection of {123I}β-CIT. Specific to nondisplaceable striatal uptake ratios (designated V3″) were correlated with Hoehn-Yahr stage and Unified Parkinson's Disease Rating Scale (UPDRS) subscores. Linear discriminant function analyses utilizing striatal uptakes, putamen-to-caudate ratios, and ipsilateral-contralateral asymmetry indices were performed. Decreased striatal tracer uptake (V3″) was correlated with total UPDRS score for both contralateral and ipsilateral striatum. Putamen uptake was relatively more reduced than caudate with mean putamen:caudate ratios of 0.50 ± 0.17 and 0.82 ± 0.09 for PD patients and controls, respectively. Ipsilateral:contralateral asymmetry was significantly greater in PD patients than controls. Discriminant function analysis utilizing V3″ for ipsilateral and contralateral caudate and putamen correctly classified all 55 cases. These data demonstrate Marchked differences in {123I}β-CIT SPECT measures in healthy controls and PD patients. The significant correlation of SPECT measures with motor severity suggests {123I}β-CIT may be a useful Marchker of disease severity in PD.

Ancillary