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Magnetically Amplified DNA Assays (MADA): Sensing of Viral DNA and Single-Base Mismatches by Using Nucleic Acid Modified Magnetic Particles

Authors

  • Fernando Patolsky,

    1. Institute of Chemistry, The Farkas Center for Light-Induced Processes, The Hebrew University of Jerusalem, Jerusalem 91904, Israel, Fax: (+972) 2-6527-715
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  • Yossi Weizmann,

    1. Institute of Chemistry, The Farkas Center for Light-Induced Processes, The Hebrew University of Jerusalem, Jerusalem 91904, Israel, Fax: (+972) 2-6527-715
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  • Eugenii Katz Dr.,

    1. Institute of Chemistry, The Farkas Center for Light-Induced Processes, The Hebrew University of Jerusalem, Jerusalem 91904, Israel, Fax: (+972) 2-6527-715
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  • Itamar Willner Prof.

    1. Institute of Chemistry, The Farkas Center for Light-Induced Processes, The Hebrew University of Jerusalem, Jerusalem 91904, Israel, Fax: (+972) 2-6527-715
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  • This research is supported by the German–Israeli Program (DIP). The Max Planck Award for International Cooperation (I.W.) is gratefully acknowledged.

Abstract

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Die verbesserte Erkennung von viraler DNA und Einzelbasenmutationen wird durch die Einführung von Biotin-Gruppen in DNA-Replika auf magnetischen Teilchen erzielt. Die Biochemolumineszenz der DNA-Erkennungs-Ereignisse kann leichter elektrokatalytisch weitergegeben werden. Durch Rotieren der magnetischen Teilchen auf einer Elektrodenoberfläche werden die einzelnen Teilschritte zusätzlich verstärkt.

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