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Design of Environment-Sensitive Supramolecular Assemblies for Intracellular Drug Delivery: Polymeric Micelles that are Responsive to Intracellular pH Change

Authors

  • Younsoo Bae,

    1. Department of Material Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139
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  • Shigeto Fukushima,

    1. Department of Material Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139
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  • Atsushi Harada,

    1. Department of Material Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139
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  • Kazunori Kataoka Prof. Dr.

    1. Department of Material Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139
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  • This work is financially supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, and by Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST). The authors acknowledge the National Cancer Center Research Institute, Japan, for supplying a human small cell lung cancer cell line SBC-3. Y.B. acknowledges financial support from the Japanese Monbusho's scholarship program.

Abstract

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“Drogenschmuggel”: Präpariert wurden Micellen aus Blockcopolymeren und dem Tumortherapeutikum Adriamycin (ADR), das über einen pH-sensitiven Linker an das Polymer gebunden ist (siehe Bild). Die Micellen gelangen durch Endocytose, unter Umgehung der Zellmembrantransporter, in die Krebszelle. Innerhalb der Zelle löst eine Senkung des pH-Wertes die Freisetzung von ADR aus, dessen Position fluoreszenzspektroskopisch bestimmt wird.

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