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Facile Construction of N-Hydroxybenzazocine: Enantioselective Total Synthesis of (+)-FR900482


  • This work was supported by CREST, the Japan Science and Technology Corporation (JST), and by the Grant-in-Aid for Scientific Research on Priority Areas (A) “Exploitation of Multi-Element Cyclic Molecules” from the Ministry of Education, Culture, Sports, Science and Technology, Japan.


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Eine intramolekulare Hydroxylaminierung des ω-Formylnitrobenzols 1 und anschließende stereoselektive Hydroxymethylierung führten zum N-Hydroxybenzazocin 2, einem Schlüsselintermediat der enantioselektiven Totalsynthese des antitumorwirksamen Antibiotikums FR900482 (3).