Pd0-Catalyzed Three-Component Tandem Double-Addition–Cyclization Reaction: Stereoselective Synthesis of cis-Pyrrolidine Derivatives

Authors

  • Shengming Ma Prof.,

    1. State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 354 Fenglin Lu, Shanghai 200032, P.R. China, Fax: (+86) 21-6416-6128
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  • Ning Jiao

    1. State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 354 Fenglin Lu, Shanghai 200032, P.R. China, Fax: (+86) 21-6416-6128
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  • Financial support from the Major State Basic Research Development Program (Grant No. G2000077500), the National Natural Science Foundation of China, and the Shanghai Municipal Committee of Science and Technology are greatly appreciated.

Abstract

original image

cis-2,5-Disubstituierte Pyrrolidin-Grundgerüste sind durch eine Pd0-katalysierte Drei-Komponenten-Tandem-Doppelcyclisierung aus 2-(2,3-Butadienyl)malonaten, Organohalogeniden und Iminen zugänglich (siehe Schema; Ausbeuten: 81–100 %, cis/trans >95:5).

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