Direct Catalytic Asymmetric Enolexo Aldolizations

Authors

  • Chandrakala Pidathala,

    1. The Scripps Research Institute, Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-7028
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  • Linh Hoang,

    1. The Scripps Research Institute, Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-7028
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  • Nicola Vignola,

    1. The Scripps Research Institute, Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-7028
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  • Benjamin List Dr.

    1. The Scripps Research Institute, Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-7028
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  • Generous support by the NIH (RO1 GM-63914) is most gratefully acknowledged. The cover picture was designed by Mike Pique (Scripps Institute) using a proline image attributed to K. N. Houk and S. Bahmanyar (UCLA). Chicken artwork courtesy of Sheri Hoeger, www.madstencilist.com © 2000.

Abstract

original image

32 Jahre nach der Beschreibung der ersten – und bisher einzigen – katalytischen asymmetrischen intramolekularen Aldolreaktion in dieser Zeitschrift wurde die Prolin-katalysierte Hajos-Parrish-Eder-Sauer-Wiechert-Reaktion auf katalytische asymmetrische enolexo-Aldolreaktionen ausgedehnt. Substituierte Cyclohexane werden dabei mit ausgezeichneten Diastereo- und Enantioselektivitäten erhalten (Beispiel siehe Schema).

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