Single-Molecule Covalent Chemistry with Spatially Separated Reactants

Authors

  • Tudor Luchian,

    1. Department of Medical Biochemistry & Genetics, The Texas A&M University System Health Science Center, 440 Reynolds Medical Building, TAMU 1114, College Station, TX 77843-1114, USA, Fax: (+1) 979-847-9481
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    • These authors contributed equally to this work.

  • Seong-Ho Shin,

    1. Department of Medical Biochemistry & Genetics, The Texas A&M University System Health Science Center, 440 Reynolds Medical Building, TAMU 1114, College Station, TX 77843-1114, USA, Fax: (+1) 979-847-9481
    2. Department of Chemistry, Texas A&M University, College Station, TX 77843, USA
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    • These authors contributed equally to this work.

  • Hagan Bayley

    1. Department of Medical Biochemistry & Genetics, The Texas A&M University System Health Science Center, 440 Reynolds Medical Building, TAMU 1114, College Station, TX 77843-1114, USA, Fax: (+1) 979-847-9481
    2. Department of Chemistry, Texas A&M University, College Station, TX 77843, USA
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  • This work was supported by the Office of Naval Research, the U.S. Department of Energy, the Multidisciplinary University Research Initiative (ONR-1999), and the National Institutes of Health. We thank Sean Conlan for help with molecular modeling.

Abstract

original image

Proteinporen als Nanoreaktoren konnten kürzlich eingesetzt werden, um die reversible kovalente Chemie einer einfachen Reaktion auf Einzelmolekül-Ebene anhand des Stroms durch die Pore zu beobachten. Jetzt ist es gelungen, eine mehrstufige Reaktion zu beobachten, bei der zwei der Reaktanten durch die Membran, welche die Pore enthält, getrennt sind und in die Reaktionszone diffundieren (siehe Bild).

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