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Transition-Metal-Based Lewis Acid and Base Ambiphilic Catalysts of Iridium Hydride Complexes: Multicomponent Synthesis of Glutarimides

Authors

  • Hikaru Takaya Dr.,

    1. Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1–3, Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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  • Kazunori Yoshida,

    1. Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1–3, Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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  • Katsuhiro Isozaki,

    1. Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1–3, Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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  • Hiroki Terai,

    1. Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1–3, Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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  • Shun-Ichi Murahashi Prof. Dr.

    1. Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1–3, Machikaneyama, Toyonaka, Osaka 560-8531, Japan
    2. Present address: Department of Chemistry, Faculty of Engineering, Okayama University of Science, 1–1, Ridaicho, Okayama 700-0005, Japan, Fax: (+81) 86-256-9513
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  • This work was supported by the “Research for the Future Program”, The Japan Society for the Promotion of Science, and a Grant-in-Aid for Scientific Research, the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

Abstract

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Balanceakt: Der Iridiumkomplex 1 ermöglicht die Durchführung säure- und basenkatalysierter Umsetzungen in einer Eintopfreaktion. Mit ihm können pharmakologisch wichtige Glutarimide in einer Dreikomponenten-Reaktion aus Nitrilen, Alkenen und Wasser aufgebaut werden (siehe Schema).

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