Practical Asymmetric Synthesis of Vicinal Diamines through the Catalytic Highly Enantioselective Alkylation of Glycine Amide Derivatives

Authors


  • This work was partially supported by the Uehara Memorial Foundation and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. M.T. thanks the Japan Society for the Promotion of Science for a Research Fellowship for Young Scientists.

Abstract

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Phasentransferkatalyse (PTC) mit einem chiralen quartären Ammoniumbromid hilft maßgeblich bei der direkten, hoch enantioselektiven Einführung einer Vielfalt von Substituenten, auch Cycloalkylgruppen, in der α-Position des prochiralen Glycinamid-Derivats 1. Dieses Verfahren bietet einen einfachen Zugang zu strukturell diversen vicinalen Diaminen 2. (Dpm=Diphenylmethyl).

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