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Parallel Fragment Assembly Strategy Towards Multiple-Ether Mimicry of Anticancer Annonaceous Acetogenins

Authors

  • Sheng Jiang Dr.,

    1. State Key Laboratory of Bioorganic, and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Road, Shanghai 200032, China, Fax: (+86) 2164166128
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  • Yan Li,

    1. Institute of Materia Medica, Chinese Academy of Medical Sciences, 1 Xiannongtan Street, Beijing 100050, China
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  • Xiao-Guang Chen Prof. Dr.,

    1. Institute of Materia Medica, Chinese Academy of Medical Sciences, 1 Xiannongtan Street, Beijing 100050, China
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  • Tai-Shan Hu Dr.,

    1. State Key Laboratory of Bioorganic, and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Road, Shanghai 200032, China, Fax: (+86) 2164166128
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  • Yu-Lin Wu Prof.,

    1. State Key Laboratory of Bioorganic, and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Road, Shanghai 200032, China, Fax: (+86) 2164166128
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  • Zhu-Jun Yao Prof. Dr.

    1. State Key Laboratory of Bioorganic, and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Road, Shanghai 200032, China, Fax: (+86) 2164166128
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  • This work was supported by the National Natural Science Foundation of China (grant no. 30271531), the Ministry of Science and Technology (MOST) of China (grant no. G2000077502), the Chinese Academy of Sciences (CAS; grant no. KGCX2-SW-209), and the Shanghai Municipal Committee of Science and Technology (grant no. 01QA14049). Dr. Terrence R. Burke, Jr. at the National Cancer Institute (NCI) is thanked for correcting the English text.

Abstract

original image

Eine Strategie zur Synthese einer kleinen Bibliothek von Annonaceen-Acetogenin-Mimetika aus Parallel-Fragmenten wurde entwickelt. Bei In-vivo-Studien zeigten einige diastereomere Analoga gute Selektivität zwischen KB- und Bel-7402-Zellen.

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