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Enzymatic Behavior by Intercalating Molecules in a Template-Directed Ligation Reaction

Authors

  • Swapan S. Jain,

    1. School of Chemistry and Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA, Fax: (+1) 404-894-2295
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  • Frank A. L. Anet Dr.,

    1. Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA
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  • Christopher J. Stahle,

    1. School of Chemistry and Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA, Fax: (+1) 404-894-2295
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  • Nicholas V. Hud Dr.

    1. School of Chemistry and Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA, Fax: (+1) 404-894-2295
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  • This work was supported by the Georgia Institute of Technology Office of the Vice Provost for Research. We thank Dr. A. Ellington (University of Texas, Austin) for helpful discussions.

Abstract

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Molekulare Geburtshilfe: Das in Nucleinsäuren intercalierende Molekül Proflavin (blaue Linie) erhöht die Basenpaarungsgeschwindigkeit kurzer Oligonucleotide um drei Größenordnungen. Mehrere Proflavinmoleküle arbeiten dabei zusammen und wirken als konzentrationsabhängiges multimolekulares „Enzym“.

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