Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora

Authors

  • Robert H. Feling Dr.,

    1. Center for Marine Biotechnology and Biomedicine Scripps Institution of Oceanography University of California, San Diego La Jolla, CA 92093-0204, USA, Fax: (+1) 858-558-3702
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  • Greg O. Buchanan Dr.,

    1. Center for Marine Biotechnology and Biomedicine Scripps Institution of Oceanography University of California, San Diego La Jolla, CA 92093-0204, USA, Fax: (+1) 858-558-3702
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  • Tracy J. Mincer,

    1. Center for Marine Biotechnology and Biomedicine Scripps Institution of Oceanography University of California, San Diego La Jolla, CA 92093-0204, USA, Fax: (+1) 858-558-3702
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  • Christopher A. Kauffman,

    1. Center for Marine Biotechnology and Biomedicine Scripps Institution of Oceanography University of California, San Diego La Jolla, CA 92093-0204, USA, Fax: (+1) 858-558-3702
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  • Paul R. Jensen,

    1. Center for Marine Biotechnology and Biomedicine Scripps Institution of Oceanography University of California, San Diego La Jolla, CA 92093-0204, USA, Fax: (+1) 858-558-3702
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  • William Fenical Prof.

    1. Center for Marine Biotechnology and Biomedicine Scripps Institution of Oceanography University of California, San Diego La Jolla, CA 92093-0204, USA, Fax: (+1) 858-558-3702
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  • Financial support was provided by the National Cancer Institute, US National Institutes of Health (under grant CA44848). We thank Dr. Peter Gantzel, University of California, San Diego, for assistance with X-ray diffraction experiments.

Abstract

original image

Starke und selektive Cytotoxizität gegenüber einer Reihe von Krebszelllinien kennzeichnen Salinosporamid A (1), das aus dem Rohextrakt eines einzigartigen marinen Aktinomyceten der Gattung Salinospora isoliert wurde.

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