Titelbild: Expanding the Functional Group Compatibility of Small-Molecule Microarrays: Discovery of Novel Calmodulin Ligands (Angew. Chem. 21/2003)

Authors

  • David Barnes-Seeman Dr.,

    1. Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, and, Harvard Institute of Chemistry and Cell Biology (ICCB), Harvard University, 12 Oxford St., Cambridge, MA 02138, USA, Fax: (+1) 617-495-0751
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  • Seung Bum Park Dr.,

    1. Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, and, Harvard Institute of Chemistry and Cell Biology (ICCB), Harvard University, 12 Oxford St., Cambridge, MA 02138, USA, Fax: (+1) 617-495-0751
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  • Angela N. Koehler Dr.,

    1. Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, and, Harvard Institute of Chemistry and Cell Biology (ICCB), Harvard University, 12 Oxford St., Cambridge, MA 02138, USA, Fax: (+1) 617-495-0751
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  • Stuart L. Schreiber Prof.

    1. Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, and, Harvard Institute of Chemistry and Cell Biology (ICCB), Harvard University, 12 Oxford St., Cambridge, MA 02138, USA, Fax: (+1) 617-495-0751
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Abstract

Mikroarrays aus kleinen Molekülen ermöglichen die robuste und skalierbare Suche nach Ligand-Protein-Wechselwirkungen. Das Titelbild zeigt das Protein Calmodulin im Komplex mit einem kleinen Molekül, das mithilfe der neuartigen “Slide-Capture”-Methode auf einer Glasoberfläche immobilisiert wurde. Mehr über diese Technik und ihre Anwendung erfahren Sie in der Zuschrift von S. L. Schreiber et al. auf S. 2478ff.

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