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Stereocontrolled Total Synthesis of (+)-Streptazolin by a Palladium-Catalyzed Reductive Diyne Cyclization

Authors


  • We thank Professor D. L. Comins for kindly providing us with the spectroscopic data for 1, and the National Institutes of Health (GM 033 049) and the National Science Foundation for their generous financial support. C.K.C. is a Stanford Graduate Fellow. Mass spectra were measured by the Mass Spectrometry Facility, University of San Francisco, supported by the NIH Division of Research Resources.

Abstract

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Neues zur (+)-Streptazolin-Synthese: Die Schlüsselreaktion einer elfstufigen Totalsynthese von (+)-Streptazolin (3), die von D-Mannitdiacetonid ausgeht, ist die Palladium-katalysierte reduktive Cyclisierung der beiden Alkinarme von 1, die das 1,3-Dien 2 mit der gewünschten Struktur liefert. TBS=tert-Butyldimethylsilyl.

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