Nickel-Catalyzed Cross-Coupling Reaction of Alkyl Halides with Organozinc and Grignard Reagents with 1,3,8,10-Tetraenes as Additives

Authors

  • Jun Terao Dr.,

    1. Department of Molecular Chemistry and Science and Technology Center for Atoms, Molecules, and Ions Control, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-7390
    Search for more papers by this author
  • Hirohisa Todo,

    1. Department of Molecular Chemistry and Science and Technology Center for Atoms, Molecules, and Ions Control, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-7390
    Search for more papers by this author
  • Hideyuki Watanabe,

    1. Department of Molecular Chemistry and Science and Technology Center for Atoms, Molecules, and Ions Control, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-7390
    Search for more papers by this author
  • Aki Ikumi,

    1. Department of Molecular Chemistry and Science and Technology Center for Atoms, Molecules, and Ions Control, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-7390
    Search for more papers by this author
  • Nobuaki Kambe Prof. Dr.

    1. Department of Molecular Chemistry and Science and Technology Center for Atoms, Molecules, and Ions Control, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-7390
    Search for more papers by this author

  • This research was supported financially in part by a Grant-in-Aid for Scientific Research. We thank the Instrumental Analysis Center, Faculty of Engineering, Osaka University, for high-resolution mass-spectrometric measurements and elemental analysis.

Abstract

original image

Die Additive bringen's: Die Zugabe von Bis(1,3-butadienyl)verbindungen (Tetraenen) war für die effiziente Ni-katalysierte Kupplung von Organozinkreagentien mit Alkylbromiden und einem Tosylat essenziell (siehe Schema, X=C(CO2Me)2 oder NCH2Ph). Auch die Effizienz der Ni-katalysierten Kupplung eines Alkylfluorids mit einem Grignard-Reagens wurde durch diese Tetraene verbessert.

Ancillary