A Highly Flexible Dinuclear Ruthenium(II)–Platinum(II) Complex: Crystal Structure and Binding to 9-Ethylguanine

Authors

  • Karlijn van der Schilden,

    1. Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands, Fax: (+31) 71-527-4671
    Search for more papers by this author
  • Fedora Garcìa,

    1. Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands, Fax: (+31) 71-527-4671
    Search for more papers by this author
  • Huub Kooijman Dr.,

    1. Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Search for more papers by this author
  • Anthony L. Spek Prof. Dr.,

    1. Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Search for more papers by this author
  • Jaap G. Haasnoot Dr.,

    1. Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands, Fax: (+31) 71-527-4671
    Search for more papers by this author
  • Jan Reedijk Prof. Dr.

    1. Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands, Fax: (+31) 71-527-4671
    Search for more papers by this author

  • This research was supported by the Council for Chemical Sciences of The Netherlands Organization for Scientific Research (CW-NWO). Support and sponsorship by COST Action D20 is kindly acknowledged. The authors thank Johnson & Matthey (Reading (UK)) for their generous loan of RuCl3x H2O and K2PtCl4 and H. den Dulk and Prof. Dr. J. Brouwer for their kind help with the preliminary cytotoxicity tests.

Abstract

original image

An der langen Leine: Wegen des langen und flexiblen Linkers im gezeigten Ruthenium-Platin-Komplex kann die Platineinheit – eventuell nach einer Präassoziation der dikationischen Rutheniumeinheit – unabhängig mit DNA durch π-π-Stapelung oder Koordination wechselwirken. Ein Prototyp dieser Klasse potenziell cytostatischer Verbindungen wird vorgestellt.

Ancillary