A Practical and Mild Method for the Highly Selective Conversion of Terminal Alkenes into Aldehydes through Epoxidation–Isomerization with Ruthenium(IV)–Porphyrin Catalysts

Authors

  • Jian Chen,

    1. Shanghai–Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences, 354 Feng Lin Road, Shanghai 200032, China
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  • Chi-Ming Che Prof. Dr.

    1. Shanghai–Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences, 354 Feng Lin Road, Shanghai 200032, China
    2. Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, Fax: (+852) 2857-1586
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  • We are thankful for the financial support of The University of Hong Kong (Generic Drugs Research Program), the Area of Excellence Scheme (AoE 10/01P) administered by the University Grants Council (HKSAR), and the Hong Kong Research Grants Council (HKU7099/01P). J.C. thanks the Croucher Foundation of Hong Kong for a postgraduate studentship.

Abstract

original image

Aldehyde in hervorragenden Ausbeuten liefert die Ruthenium-Porphyrin-katalysierte Oxidation von terminalen Alkenen mit 2,6-Dichlorpyridin-N-oxid unter milden Bedingungen. Die Aldehyde können in situ für Olefinierungsreaktionen mit Ethyldiazoacetat in Gegenwart von PPh3 in einem Eintopfprozess genutzt werden (siehe Beispiel).

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