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Pd-Catalyzed Amination of Nucleoside Arylsulfonates to yield N6-Aryl-2,6-Diaminopurine Nucleosides

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  • This work was supported by NSF grant CHE-0314326 and a PSC-CUNY 35 award. Acquisition of a 500 MHz NMR spectrometer was funded by NSF grant CHE-0210295. Professor S. L. Buchwald (MIT) is thanked for a sample of L 5, and Dr. G. Li (CombiPhos Catalysts Inc.) is thanked for samples of L 6 and L 7.

Abstract

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Die Substituenten beider Reaktanten (Nucleosidarylsulfonat und Arylamin) beeinflussen deren Kupplung zu 2,6-Diaminopurin-2′-desoxyribonucleosiden (siehe Schema) erheblich. Eine systematische Studie der Liganden des Pd-Katalysators in Aminierungen und C-C-Kupplungen liefert Einblicke in die Strukturelemente, die für eine effiziente Katalyse wesentlich sind.

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