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A DMSO-Compatible Orienting Medium: Towards the Investigation of the Stereochemistry of Natural Products

Authors

  • Peter Haberz Mag.,

    1. Max Planck Institut for Biophysical Chemistry, Abt. 030: NMR-Based Structural Biology, Am Fassberg 11, 37 077 Göttingen, Germany, Fax: (+49) 551-201-2202
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  • Jonathan Farjon Dr.,

    1. Max Planck Institut for Biophysical Chemistry, Abt. 030: NMR-Based Structural Biology, Am Fassberg 11, 37 077 Göttingen, Germany, Fax: (+49) 551-201-2202
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  • Christian Griesinger Prof. Dr.

    1. Max Planck Institut for Biophysical Chemistry, Abt. 030: NMR-Based Structural Biology, Am Fassberg 11, 37 077 Göttingen, Germany, Fax: (+49) 551-201-2202
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Errata

This article is corrected by:

  1. Errata: A DMSO-Compatible Orienting Medium: Towards the Investigation of the Stereochemistry of Natural Products Volume 119, Issue 41, 7874, Article first published online: 4 October 2007

  • This work was supported by the DFG (SFB 472-Z-project), the Max Planck Gesellschaft, and the Fonds der Chemischen Industrie. J.F. is supported by a grant from the DAAD. We are grateful to Markus Radzom and Axel Zeeck for providing the hormaomycin, to Uwe Reinscheid for help with the hormaomycin spectra, to Hui Geng and Heike Neubauer for the preparation of the decasaccharide, to Christophe Farès and Jochen Junker for useful editorial advice, as well as to Markus Zweckstetter for very helpful discussions concerning the program PALES.

Abstract

original image

Organische Moleküle unterschiedlicher Komplexität werden durch ein DMSO-kompatibles Gel so ausgerichtet, dass dipolare C-H-Kopplungen bis 29 Hz beobachtbar sind. Dies ebnet den Weg zur simultanen NMR-spektroskopischen Bestimmung der Konformation und Konfiguration organischer Verbindungen und somit der Stereochemie von Naturstoffen, die nicht kristallisiert werden können (z. B. Hormaomycin, siehe Bild).

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