This work was supported by a Grant-in-Aid for Scientific Research, the Ministry of Education, Culture, Sports, Science, and Technology, Japan. N.T. thanks the Japan Society for the Promotion of Science for the award of a fellowship for graduate students.
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Zuschrift
Asymmetric Synthesis of Diarylmethyl Amines by Rhodium-Catalyzed Asymmetric Addition of Aryl Titanium Reagents to Imines†
Article first published online: 17 NOV 2004
DOI: 10.1002/ange.200461338
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Hayashi, T., Kawai, M. and Tokunaga, N. (2004), Asymmetric Synthesis of Diarylmethyl Amines by Rhodium-Catalyzed Asymmetric Addition of Aryl Titanium Reagents to Imines. Angewandte Chemie, 116: 6251–6254. doi: 10.1002/ange.200461338
- †
Publication History
- Issue published online: 17 NOV 2004
- Article first published online: 17 NOV 2004
- Manuscript Received: 16 JUL 2004
Keywords:
- Amine;
- Arylierungen;
- Asymmetrische Katalyse;
- Rhodium;
- Titan
Graphical Abstract
Rationales Justieren der Arensulfonamid-Einheit (durch das Einführen von Isopropylgruppen) bewirkte eine hohe Enantioselektivität in der asymmetrischen Synthese von (Diarylmethyl)aminen durch die Titelreaktion (siehe Schema). Ar1=4-CF3C6H4, 4-ClC6H4, 4-FC6H4, 3-MeOC6H4, 4-MeOC6H4, 2-MeC6H4, 1-Naphthyl, Ph; Ar2=Ph, 4-FC6H4, 3-MeOC6H4, 4-MeOC6H4.