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Asymmetric Synthesis of Diarylmethyl Amines by Rhodium-Catalyzed Asymmetric Addition of Aryl Titanium Reagents to Imines


  • This work was supported by a Grant-in-Aid for Scientific Research, the Ministry of Education, Culture, Sports, Science, and Technology, Japan. N.T. thanks the Japan Society for the Promotion of Science for the award of a fellowship for graduate students.


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Rationales Justieren der Arensulfonamid-Einheit (durch das Einführen von Isopropylgruppen) bewirkte eine hohe Enantioselektivität in der asymmetrischen Synthese von (Diarylmethyl)aminen durch die Titelreaktion (siehe Schema). Ar1=4-CF3C6H4, 4-ClC6H4, 4-FC6H4, 3-MeOC6H4, 4-MeOC6H4, 2-MeC6H4, 1-Naphthyl, Ph; Ar2=Ph, 4-FC6H4, 3-MeOC6H4, 4-MeOC6H4.