Supramolecular Nanocarrier of Anionic Dendrimer Porphyrins with Cationic Block Copolymers Modified with Polyethylene Glycol to Enhance Intracellular Photodynamic Efficacy

Authors

  • Woo-Dong Jang Dr.,

    1. Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139
    2. CREST, Japan Science and Technology Corporation, Japan
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  • Nobuhiro Nishiyama Dr.,

    1. Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139
    2. Department of Clinical Vascular Regeneration, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
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  • Guo-Dong Zhang Dr.,

    1. Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139
    2. CREST, Japan Science and Technology Corporation, Japan
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  • Atsushi Harada Dr.,

    1. Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139
    2. CREST, Japan Science and Technology Corporation, Japan
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  • Dong-Lin Jiang Dr.,

    1. Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
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  • Satoko Kawauchi Dr.,

    1. Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
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  • Yuji Morimoto Dr.,

    1. Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
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  • Makoto Kikuchi Prof. Dr.,

    1. Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan
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  • Hiroyuki Koyama Dr.,

    1. Department of Clinical Vascular Regeneration, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
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  • Takuzo Aida Prof. Dr.,

    1. Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
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  • Kazunori Kataoka Prof. Dr.

    1. Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139
    2. CREST, Japan Science and Technology Corporation, Japan
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  • This work was supported by Core Research for Evolutional Science and Technology (CREST), JST.

Abstract

original image

Photocytotoxisch und stabil ist das polymere Micellensystem, das in wässrigem Medium durch elektrostatische Assoziation aus einem anionischen dendrimeren Porphyrin und einem Polyethylenglycol-Poly(L-lysin)-Blockcopolymer entsteht (siehe Bild). Wegen seiner hydrodynamischen Größe (ca. 60 nm) sollte sich dieses polymere Micellensystem für die intravenöse Verabreichung bei der photodynamischen Tumortherapie eignen.

Ancillary