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Multifunctional Nanoparticles Possessing A “Magnetic Motor Effect” for Drug or Gene Delivery

Authors

  • Tae-Jong Yoon,

    1. Materials Chemistry Laboratory, School of Chemistry, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-882-1080
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    • These authors contributed equally to this work.

  • Jun Sung Kim,

    1. Laboratory of Toxicology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-873-1268
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    • These authors contributed equally to this work.

  • Byung Geol Kim,

    1. Materials Chemistry Laboratory, School of Chemistry, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-882-1080
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  • Kyeong Nam Yu,

    1. Laboratory of Toxicology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-873-1268
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  • Myung-Haing Cho Prof.,

    1. Laboratory of Toxicology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-873-1268
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  • Jin-Kyu Lee Prof.

    1. Materials Chemistry Laboratory, School of Chemistry, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-882-1080
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  • This work is supported by Nano Systems Institute-National Core Research Center (NSI-NCRC), Korea Science and Engineering Foundation (KOSEF). T.-J.Y, J.S.K, B.-G.K, and K.N.Y are grateful for the award of a BK21 fellowship. We thank Prof. Seung Bum Park for his valuable comments and Ms. Eun Jung Kang for her help with CLSM investigations. “Magnetic motor effect”: cell movement as a result of applying an external magnetic field to cells containing magnetic nanoparticles.

Abstract

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Zellen in Bewegung: Multifunktionelle, biokompatible Nanopartikel mit einer einzigartigen Kombination von magnetischen und Fluoreszenzeigenschaften wurden hergestellt. Anschließend wurde ihre Aufnahme durch Zellen untersucht und ein externer „Magnetmotoreffekt“ auf die Nanopartikel-haltigen Zellen nachgewiesen (siehe Schema).

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