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Convergent Diversity-Oriented Synthesis of Small-Molecule Hybrids

Authors

  • Chuo Chen Dr.,

    1. Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University and The Broad Institute of Harvard and MIT, 12 Oxford Street, Cambridge, MA 02138, USA, Fax: (+1) 617-495-0751
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    • These authors contributed equally to this work.

  • Xiaodong Li,

    1. Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University and The Broad Institute of Harvard and MIT, 12 Oxford Street, Cambridge, MA 02138, USA, Fax: (+1) 617-495-0751
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    • These authors contributed equally to this work.

  • Christopher S. Neumann,

    1. Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University and The Broad Institute of Harvard and MIT, 12 Oxford Street, Cambridge, MA 02138, USA, Fax: (+1) 617-495-0751
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  • Michael M.-C. Lo Dr.,

    1. Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University and The Broad Institute of Harvard and MIT, 12 Oxford Street, Cambridge, MA 02138, USA, Fax: (+1) 617-495-0751
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  • Stuart L. Schreiber Prof.

    1. Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University and The Broad Institute of Harvard and MIT, 12 Oxford Street, Cambridge, MA 02138, USA, Fax: (+1) 617-495-0751
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  • We thank the NIGMS for support of this research. C.C. is a research associate and S.L.S is an investigator with the Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University. C.S.N. acknowledges an NSF predoctoral fellowship.

Abstract

original image

Komplexe Bibliotheken kleiner Moleküle wurden durch einen konvergenten Ansatz mit kurzer linearer Sequenz erhalten: die Hybridbibliothek IV und die Hybridbibliothek V mit Elementen aus der Unterbibliothek II (anellierte Pyrrolidine) und den Unterbibliotheken I (überbrückte Piperidine) bzw. III (spirocyclische Oxindole). II=RII[BOND]COOH.

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