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Asymmetric Amplification Using Chiral Cocrystals Formed from Achiral Organic Molecules by Asymmetric Autocatalysis

Authors

  • Tsuneomi Kawasaki Dr.,

    1. Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan, Fax: (+81) 3-3235-2214
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  • Kazumichi Jo,

    1. Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan, Fax: (+81) 3-3235-2214
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  • Hirotaka Igarashi,

    1. Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan, Fax: (+81) 3-3235-2214
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  • Itaru Sato Dr.,

    1. Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan, Fax: (+81) 3-3235-2214
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  • Masaki Nagano,

    1. Department of Applied Chemistry, Faculty of Engineering, Ehime University, Matsuyama, Ehime 790-8577, Japan
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  • Hideko Koshima Prof. Dr.,

    1. Department of Applied Chemistry, Faculty of Engineering, Ehime University, Matsuyama, Ehime 790-8577, Japan
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  • Kenso Soai Prof. Dr.

    1. Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan, Fax: (+81) 3-3235-2214
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  • This work was supported by a Grant-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science, and Technology (MEXT).

Abstract

original image

Enantioselektiv addiert Diisopropylzink an einen Pyrimidin-5-carbaldehyd in Gegenwart chiraler Cokristalle aus achiralen Zweikomponenten-Molekülkristallen von Tryptamin/para-Chlorbenzoesäure (siehe Schema) und 3-Indolpropionsäure/Phenanthridin. Diese Reaktion lieferte in Kombination mit asymmetrischer Autokatalyse ein Pyrimidylalkanol in hohem Enantiomerenüberschuss.

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