Ultra-rapid Synthesis of 15O-Labeled 2-Deoxy-D-glucose for Positron Emission Tomography (PET)

Authors

  • Hideki Yorimitsu Dr.,

    1. University of Tokyo, Department of Chemistry, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81) 3-5800-6889
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  • Yoshihiro Murakami Dr.,

    1. Advanced Technology Platform Research Laboratory, Fujisawa Pharmaceutical Co. Ltd. 5-2-3, Tokodai, Tsukuba, Ibaraki 300-2698, Japan
    2. The Medical and Pharmacological Research Center Foundation, Wo32, Inoyama-cho, Hakui, Ishikawa 925-0613, Japan
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  • Hiroyuki Takamatsu Dr.,

    1. Advanced Technology Platform Research Laboratory, Fujisawa Pharmaceutical Co. Ltd. 5-2-3, Tokodai, Tsukuba, Ibaraki 300-2698, Japan
    2. The Medical and Pharmacological Research Center Foundation, Wo32, Inoyama-cho, Hakui, Ishikawa 925-0613, Japan
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  • Shintaro Nishimura Dr.,

    1. Advanced Technology Platform Research Laboratory, Fujisawa Pharmaceutical Co. Ltd. 5-2-3, Tokodai, Tsukuba, Ibaraki 300-2698, Japan
    2. The Medical and Pharmacological Research Center Foundation, Wo32, Inoyama-cho, Hakui, Ishikawa 925-0613, Japan
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  • Eiichi Nakamura Prof.

    1. University of Tokyo, Department of Chemistry, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81) 3-5800-6889
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  • This work was supported by a Grant-in-Aid for the 21st century COE Program for Frontiers in Fundamental Chemistry from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to E.N.), and by a postdoctoral research fellowship for SPD from the Japan Society for the Promotion of Science (to H.Y.). We thank Dr. Akihiro Noda for assistance with PPIS imaging and Dr. Masahiro Yamanaka and Dr. Cecile Savarin for their important previous contributions.

Abstract

original image

Es muss schnell gehen! Das Sauerstoffisotop 15O, das eine Halbwertszeit von nur 2 min hat, wurde durch eine ultraschnelle radikalische Hydroxylierung, bei der 2,6-Didesoxy-6-iod-D-glucose durch markierten molekularen Sauerstoff in 6-[15O]-2-Desoxy-D-glucose umgewandelt wird, in ein Zuckermolekül eingebaut (siehe Schema). Das Produkt reichert sich auf ähnliche Weise wie ein gängiger 18F-Tracer in metabolisch aktiven Organen der Ratte an, was es zu einem vielversprechenden Mittel für Bildgebungsverfahren in der Medizin macht.

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