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Direct Organocatalytic and Highly Enantio- and Diastereoselective Mannich Reactions of α-Substituted α-Cyanoacetates

Authors

  • Thomas B. Poulsen,

    1. The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Carlos Alemparte Dr.,

    1. The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Steen Saaby Dr.,

    1. The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Marco Bella Dr.,

    1. The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Karl Anker Jørgensen Prof. Dr.

    1. The Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • This work was made possible by a grant from The Danish National Research Foundation. We are grateful to Dr. Jacob Overgaard for X-ray crystallographic analysis.

Abstract

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Metallfreie Katalyse: Hoch funktionalisierte Moleküle mit zwei benachbarten Stereozentren sind mit einem käuflichen Organokatalysator einfach, in hoher Ausbeute und mit hoher Enantio- und Diastereoselektivität zugänglich (siehe Schema). Die leicht zu entfernende Boc-Schutzgruppe im Produkt ist ein zusätzlicher Vorteil dieser Methode.

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