We thank Prof. K. Saigo and Dr. Y. Ishida (The University of Tokyo) for the use of a high-pressure mercury lamp. This work was partially supported by a Grand-in-Aid for Scientific Research on Priority Area (A): “Creation of Biologically Functional Molecules”, from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
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Zuschrift
Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes†
Article first published online: 1 JUN 2005
DOI: 10.1002/ange.200500599
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Hayashi, Y., Gotoh, H., Hayashi, T. and Shoji, M. (2005), Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes. Angewandte Chemie, 117: 4284–4287. doi: 10.1002/ange.200500599
- †
Publication History
- Issue published online: 23 JUN 2005
- Article first published online: 1 JUN 2005
- Manuscript Revised: 19 APR 2005
- Manuscript Received: 17 FEB 2005
Keywords:
- Asymmetrische Katalyse;
- Diphenylprolinol;
- Michael-Additionen;
- Nitroalkene;
- Organokatalyse
Graphical Abstract
Die direkte, katalytische, asymmetrische Michael-Addition von Aldehyden an Nitroolefine in Gegenwart eines chiralen Diphenylprolinolsilylether-Organokatalysators (siehe Schema) liefert hoch syn-diastereoselektiv die gewünschten 1,4-Addukte in nahezu optisch reiner Form und guter Ausbeute. TMS=Trimethylsilyl.