Alzheimer's Disease Related Copper(II)- β-Amyloid Peptide Exhibits Phenol Monooxygenase and Catechol Oxidase Activities

Authors

  • Giordano F. Z. da Silva,

    1. Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 E. Fowler Avenue, SCA400, Tampa, FL 33620-5250, USA, Fax: (+1) 813-974-3203
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  • Li-June Ming Prof.

    1. Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 E. Fowler Avenue, SCA400, Tampa, FL 33620-5250, USA, Fax: (+1) 813-974-3203
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  • G.F.Z.S. dedicates this work to his parents for their unyielding support. The authors dedicate this work to the Kelley and Sotolongo families for their unfortunate experience with Alzheimer's disease. Our research on the structure and activity of metallopeptides was partially supported by the Research and Creative Award of the University of South Florida and the Petroleum Research Fund administrated by the American Chemical Society (PRF AC #40851-AC3). We thank John Kelley for the modification of the picture for the Table of Contents.

Abstract

original image

Grauzone in den grauen Zellen: Der CuII-Komplex eines verkürzten β-Amyloids, CuAβ1–20, beschleunigt die Oxidation von Brenzcatechin und die Hydroxylierung und Oxidation von Phenol (siehe Bild) drastisch (Faktor 105–106). Die Cu-O-Chemie von CuAβ könnte zu einem gründlicheren Verständnis der chemischen Wirkung in den Gehirnen von Alzheimer-Patienten und zu möglichen Behandlungsstrategien für diese Erkrankung beitragen.

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