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Ruthenium-Catalyzed Oxidative Cyanation of Tertiary Amines with Hydrogen Peroxide and Sodium Cyanide

Authors

  • Shun-Ichi Murahashi Prof. Dr.,

    1. Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1–3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
    2. Present address: Department of Applied Chemistry, Faculty of Engineering, Okayama University of Science, 1–1 Ridaicho, Okayama, Okayama 700-0005, Japan, Fax: (+81) 86-256-9513
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  • Naruyoshi Komiya Dr.,

    1. Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1–3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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  • Hiroyuki Terai

    1. Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1–3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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  • This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

Abstract

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Vielseitige Zwischenstufen zur Synthese von N-Aryl-α-aminosäuren und N,N-disubstituierten 1,2-Diaminen sind durch Ruthenium-katalysierte oxidative Cyanierung von tertiären Aminen zugänglich. Die Verwendung von Wasserstoffperoxid als Oxidationsmittel in Gegenwart von NaCN/AcOH oder HCN liefert die entsprechenden α-Aminonitrile (siehe Schema).

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