Facile Synthesis of Chiral α-Difluoromethyl Amines from N-(tert-Butylsulfinyl)aldimines

Authors

  • Ya Li,

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Feng-Lin Rd., Shanghai, 200032, China, Fax: (+86) 21-64166128
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  • Jinbo Hu Prof. Dr.

    1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Feng-Lin Rd., Shanghai, 200032, China, Fax: (+86) 21-64166128
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  • Dedicated to Prof. George A. Olah on the occasion of his receipt of the 2005 Priestley Medal. Support of our work by the “Hundreds Talent Program” from the Chinese Academy of Sciences is gratefully acknowledged.

Abstract

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Die nucleophile (Phenylsulfonyl)difluormethylierung von (R)-(N-tert-Butylsulfinyl)aldiminen mit (Difluormethyl)phenylsulfon verläuft mit ausgezeichneten Ausbeuten und hoher Diastereoselektivität (siehe Schema). Das unproblematische Entschützen von tert-Butylsulfinyl- und Phenylsulfonylgruppen liefert die gewünschten α-Difluormethylamine in hoher Enantiomerenreinheit.

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