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Organocatalytic Asymmetric α-Halogenation of 1,3-Dicarbonyl Compounds

Authors

  • Giuseppe Bartoli Prof.,

    1. Department of Organic Chemistry “A. Mangini”, Alma Mater Studiorum, Bologna University, Viale Risorgimento, 4, 40136 Bologna, Italy, Fax:(+39) 051-209-3654
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  • Marcella Bosco Prof.,

    1. Department of Organic Chemistry “A. Mangini”, Alma Mater Studiorum, Bologna University, Viale Risorgimento, 4, 40136 Bologna, Italy, Fax:(+39) 051-209-3654
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  • Armando Carlone Dr.,

    1. Department of Organic Chemistry “A. Mangini”, Alma Mater Studiorum, Bologna University, Viale Risorgimento, 4, 40136 Bologna, Italy, Fax:(+39) 051-209-3654
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  • Manuela Locatelli Dr.,

    1. Department of Organic Chemistry “A. Mangini”, Alma Mater Studiorum, Bologna University, Viale Risorgimento, 4, 40136 Bologna, Italy, Fax:(+39) 051-209-3654
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  • Paolo Melchiorre Dr.,

    1. Department of Organic Chemistry “A. Mangini”, Alma Mater Studiorum, Bologna University, Viale Risorgimento, 4, 40136 Bologna, Italy, Fax:(+39) 051-209-3654
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  • Letizia Sambri Dr.

    1. Department of Organic Chemistry “A. Mangini”, Alma Mater Studiorum, Bologna University, Viale Risorgimento, 4, 40136 Bologna, Italy, Fax:(+39) 051-209-3654
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Errata

This article is corrected by:

  1. Errata: Organocatalytic Asymmetric α-Halogenation of 1,3-Dicarbonyl Compounds Volume 118, Issue 3, 348, Article first published online: 5 January 2006

  • This work was carried out in the framework of the National Project “Stereoselezione in Sintesi Organica: Metodologie e Applicazioni” supported by the MIUR, Rome, and the FIRB National Project “Progettazione, preparazione e valutazione biologica e farmacologica di nuove molecole organiche quali potenziali farmaci innovativi”.

Abstract

original image

Metallfrei: Ein Verfahren für die enantioselektive organokatalytische Chlorierung cyclischer und acyclischer β-Ketoester sowie cyclischer β-Diketone wurde entwickelt, das außerdem die asymmetrische Bromierung von β-Ketoestern ermöglicht. Die Methode beruht auf einem billigen Organokatalysator (z. B. Benzoylchinidin) und polyhalogenierten Chinolinonen als Halogenquelle (siehe Schema).

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