Selective Sensing of Zinc Ions with a PARACEST Contrast Agent

Authors

  • Robert Trokowski Dr.,

    1. Department of Chemistry, The University of Texas at Dallas, P.O. Box 830688, Richardson, TX 75080, USA, Fax: (+1) 972-883-2925
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  • Jimin Ren Dr.,

    1. The Rogers Magnetic Resonance Center, Department of Radiology, University of Texas, Southwestern Medical Center, 5801 Forest Road, Dallas, TX 75235, USA
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  • Ferenc Krisztián Kálmán,

    1. Department of Chemistry, The University of Texas at Dallas, P.O. Box 830688, Richardson, TX 75080, USA, Fax: (+1) 972-883-2925
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  • A. Dean Sherry Prof.

    1. Department of Chemistry, The University of Texas at Dallas, P.O. Box 830688, Richardson, TX 75080, USA, Fax: (+1) 972-883-2925
    2. The Rogers Magnetic Resonance Center, Department of Radiology, University of Texas, Southwestern Medical Center, 5801 Forest Road, Dallas, TX 75235, USA
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  • This work was supported in part by grants from the Robert A. Welch Foundation (AT-584), the National Institutes of Health (CA-84697), the Division of Research Resources, the National Institutes of Health (RR-02584), and the Texas Advanced Technology Program. PARACEST=paramagnetic chemical exchange saturation transfer.

Abstract

original image

Ein Europiumkomplex, der selektiv Zinkionen bindet (siehe Bild), wurde entwickelt und als neue paramagnetische chemische Austauschsättigungstransfer(PARACEST)-Imagingsubstanz in der Kernspintomographie (MRI) getestet. Ein Hydroxoligand am Zn-Ion beschleunigt den Wasseraustausch am Eu-Ion.

Ancillary