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In(OTf)3-Catalyzed Tandem Nucleophilic Addition and Cyclization of ortho-Alkynylarylaldimines to 1,2-Dihydroisoquinolines


  • This work was supported by grants from 21st Century COE Program “Knowledge Information Infrastructure for Genome Sciences” and Grant-in-Aid for Scientific Research on Priority Areas from MEXT (17035043), and JSPS. KAKENHI (16390006). S.O. thanks the JSPS for a Fellowship. OTf=trifluoromethanesulfonate.


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Doppelkatalysator: Eine In(OTf)3-katalysierte Tandemanellierung führt in hohen Ausbeuten zu 1,2-Dihydroisochinolinen. Der Katalysator aktiviert die Imin- und die Alkingruppe für die Addition von Nucleophilen und anschließende intramolekulare Cyclisierung (siehe Schema; OTf=Trifluormethansulfonat).

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