Rolling-Circle Amplification of a DNA Nanojunction

Authors

  • Chenxiang Lin,

    1. Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA, Fax: (+1) 480-727-2378
    2. The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
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  • Mingyi Xie,

    1. Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA, Fax: (+1) 480-727-2378
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  • Julian J. L. Chen Prof. Dr.,

    1. Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA, Fax: (+1) 480-727-2378
    2. School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
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  • Yan Liu Dr.,

    1. Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA, Fax: (+1) 480-727-2378
    2. The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
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  • Hao Yan Prof. Dr.

    1. Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA, Fax: (+1) 480-727-2378
    2. The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
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  • This work has been supported by grants from the NSF (CCF-0453685, CCF-0453686, and CTS-0545652) and research grants from the Biodesign Institute at ASU to H.Y.

Abstract

original image

DNA bekommt Gesellschaft: Durch das „Rolling-circle“-Amplifikationsverfahren wurde ein vierarmiges DNA-Kreuzungsmotiv vervielfältigt. Unter geeigneten Bedingungen gelingt diese Vervielfältigung effizient und fehlerfrei, sodass die enzymatische Synthese von DNA-Nanostrukturen im großen Maßstab möglich wird.

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