An Aptamer–Doxorubicin Physical Conjugate as a Novel Targeted Drug-Delivery Platform

Authors

  • Vaishali Bagalkot,

    1. Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryoung-dong, Buk-gu, Gwangju 500712, South Korea, Fax: (+82) 62-970-2504
    2. Department of Anaesthesiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA, Fax: (+1) 617-730-2801
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  • Omid C. Farokhzad Prof. Dr.,

    1. Department of Anaesthesiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA, Fax: (+1) 617-730-2801
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  • Robert Langer Prof. Dr.,

    1. Department of Chemical Engineering, Massachusetts Institute of Technology, E25-342, 45 Carleton Street, Cambridge, MA 02139, USA
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  • Sangyong Jon Prof. Dr.

    1. Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryoung-dong, Buk-gu, Gwangju 500712, South Korea, Fax: (+82) 62-970-2504
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  • This work was supported by Korea Science and Technology Foundation grant R01-2006-000-10818-0 (S.J. and V.B.) and USA National Institutes of Health grants CA 119349 (R.L., O.F., and V.B.) and EB 003647 (O.F.). We also thank Prof. C. S. Park for helpful discussions. This work is dedicated to the families of patients with cancer.

Abstract

original image

Trojanisches Aptamer: Eine neuartige Strategie für den gezielten Transport von Wirkstoffen zu Krebszellen beruht auf der Bildung eines physikalischen Konjugats (siehe Schema) zwischen Doxorubicin (Dox) und dem A10-RNA-Aptamer, das an das Prostata-spezifische Membranantigen (PSMA) bindet. Das Aptamer-Dox-Konjugat band effizient an PSMA-exprimierende Zellen; dabei wurde das Aptamer in die Zelle aufgenommen und schließlich Dox intrazellulär freigesetzt.

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