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Designed Fabrication of Multifunctional Magnetic Gold Nanoshells and Their Application to Magnetic Resonance Imaging and Photothermal Therapy

Authors

  • Jaeyun Kim,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
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    • These authors contributed equally to this work.

  • Sungjin Park,

    1. Laboratory of Toxicology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-873-1268
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    • These authors contributed equally to this work.

  • Ji Eun Lee,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
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  • Seung Min Jin Dr.,

    1. School of Chemistry, Seoul National University, Seoul 151-744, Korea
    2. Present address: Advanced Materials Division, Korea Research Institute of Chemical Technology, Daejeon 305-343, Korea
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  • Jung Hee Lee Prof. Dr.,

    1. Department of Radiology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 137-200, Korea
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  • In Su Lee Dr.,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
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  • Ilseung Yang,

    1. School of Chemistry, Seoul National University, Seoul 151-744, Korea
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  • Jun-Sung Kim,

    1. Laboratory of Toxicology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-873-1268
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  • Seong Keun Kim Prof. Dr.,

    1. School of Chemistry, Seoul National University, Seoul 151-744, Korea
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  • Myung-Haing Cho Prof. Dr.,

    1. Laboratory of Toxicology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-873-1268
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  • Taeghwan Hyeon Prof. Dr.

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
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  • T.H. acknowledges financial support by the Korean Ministry of Science and Technology through the National Creative Research Initiative Program of the Korea Science and Engineering Foundation (KOSEF). M.H.C. is supported by the NSI-NCRC program of KOSEF. S.K.K. is supported by a National Research Laboratory Grant and a Chemical Genomics Grant. J.H.L. is supported by the Centre for Biological Modulators of the 21st Century Frontier R&D Program.

Abstract

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Krebs im Visier: Multifunktionelle magnetische Gold-Nanoschalen (Mag-GNS) entstehen beim Beschichten von Siliciumoxid-Kugeln mit Gold-Nanoschalen, in die Fe3O4-Nanopartikel eingelagert sind. Die Fe3O4-Nanopartikel ermöglichen eine kernspintomographische Diagnose (MRI) und die Gold-Nanoschalen eine photothermische Therapie. Nach Anbinden eines Antikörpers an die Mag-GNS über einen Polyethylenglycol(PEG)-Linker lassen sich Krebszellen gezielt ansteuern.

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