This work was supported by the Max-Planck-Gesellschaft, the Volkswagen-Stiftung (Grant no. I/80 798 to T.C.), by the European Union (Marie Curie fellowship to V.M.S.-P.), and by the DAAD (Postdoctoral fellowship PKZ A/06/04203 to K.K). We thank Christian Griesinger for critical reading of this manuscript and useful discussions, Marcel Reese for support, and Holger Stark for the electron microscopy studies. I.P. thanks Novartis Pharma AG for financial support.
The Tubulin-Bound Conformation of Discodermolide Derived by NMR Studies in Solution Supports a Common Pharmacophore Model for Epothilone and Discodermolide†
Article first published online: 12 OCT 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 118, Issue 44, pages 7548–7554, November 13, 2006
How to Cite
Sánchez-Pedregal, V. M., Kubicek, K., Meiler, J., Lyothier, I., Paterson, I. and Carlomagno, T. (2006), The Tubulin-Bound Conformation of Discodermolide Derived by NMR Studies in Solution Supports a Common Pharmacophore Model for Epothilone and Discodermolide. Angew. Chem., 118: 7548–7554. doi: 10.1002/ange.200602793
- Issue published online: 6 NOV 2006
- Article first published online: 12 OCT 2006
- Manuscript Received: 13 JUL 2006
- Volkswagen-Stiftung. Grant Number: I/80 798
- European Union
- DAAD. Grant Number: PKZ A/06/04203
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