This research was supported by the NIH (CA087660), the Howard Hughes Medical Institute (predoctoral fellowship to K.T.B.), and the Skaggs Institute for Chemical Biology. We thank M. Patricelli (Activx Biosciences) for assistance with the identification of probe sites of labeling for nitrilase enzymes and the members of the Cravatt lab for helpful discussions and critical reading of the manuscript.
Substrate Mimicry in an Activity-Based Probe That Targets the Nitrilase Family of Enzymes†
Version of Record online: 11 OCT 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 118, Issue 44, pages 7568–7571, November 13, 2006
How to Cite
Barglow, K. T. and Cravatt, B. F. (2006), Substrate Mimicry in an Activity-Based Probe That Targets the Nitrilase Family of Enzymes. Angew. Chem., 118: 7568–7571. doi: 10.1002/ange.200603187
- Issue online: 6 NOV 2006
- Version of Record online: 11 OCT 2006
- Manuscript Received: 5 AUG 2006
- NIH. Grant Number: CA087660
- Howard Hughes Medical Institute
- Skaggs Institute for Chemical Biology
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