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Selective Extraction of Peptides from Human Plasma by Highly Ordered Mesoporous Silica Particles for Peptidome Analysis

Authors

  • Ruijun Tian,

    1. National Chromatographic R&A Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China, Fax: (+86) 411-84379620
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  • He Zhang,

    1. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics (DICP), The Chinese Academy of Sciences, Dalian 116023, China
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  • Mingliang Ye Prof. Dr.,

    1. National Chromatographic R&A Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China, Fax: (+86) 411-84379620
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  • Xiaogang Jiang,

    1. National Chromatographic R&A Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China, Fax: (+86) 411-84379620
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  • Lianghai Hu,

    1. National Chromatographic R&A Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China, Fax: (+86) 411-84379620
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  • Xin Li,

    1. National Chromatographic R&A Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China, Fax: (+86) 411-84379620
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  • Xinhe Bao Prof. Dr.,

    1. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics (DICP), The Chinese Academy of Sciences, Dalian 116023, China
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  • Hanfa Zou Prof. Dr.

    1. National Chromatographic R&A Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China, Fax: (+86) 411-84379620
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  • This work was supported by the National Natural Sciences Foundation of China (No. 20327002), a China State Key Basic Research Program Grant (2005 CB522701), and the Knowledge Innovation Program of DICP to H.Z.

Abstract

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Poren zeigen Wirkung: Mit Siliciumoxidpartikeln mit einer Porengröße von 20.5 Å (siehe TEM-Bild) gelingt die Anreicherung von Peptiden mit Molekulargewichten von 1 bis 12 kDa in Humanplasma; andere Plasmaproteine werden dagegen nicht angereichert. Durch seine Porenstruktur ist das Material besser für die Peptidanreicherung geeignet als Adsorbens- und Ultrafiltrationsmethoden.

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