Zuschrift

siRNA Delivery into Human T Cells and Primary Cells with Carbon-Nanotube Transporters†

  1. Zhuang Liu1,
  2. Mark Winters Dr.2,
  3. Mark Holodniy Dr.2,3,
  4. Hongjie Dai Prof.1

Article first published online: 9 FEB 2007

DOI: 10.1002/ange.200604295

Issue

Angewandte Chemie

Angewandte Chemie

Volume 119, Issue 12, pages 2069–2073, March 12, 2007

Additional Information

How to Cite

Liu, Z., Winters, M., Holodniy, M. and Dai, H. (2007), siRNA Delivery into Human T Cells and Primary Cells with Carbon-Nanotube Transporters. Angewandte Chemie, 119: 2069–2073. doi: 10.1002/ange.200604295

Author Information

  1. 1

    Department of Chemistry, Stanford University, Stanford, CA 94305, USA, Fax: (+1) 650-725-0259

  2. 2

    Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA 94305, USA

  3. 3

    Palo Alto Health Care System, Stanford, CA 94305, USA

  1. †

    We thank the NIH AIDS Reagent Program for providing the three human T cell lines and two MAGI cell lines. This research was supported in part by the Ludwig Translational Research Program at Stanford University and a grant from the NIH/NCI Center for Cancer Nanotechnology Excellence (CCNE). siRNA=short interfering RNA.

Publication History

  1. Issue published online: 2 MAR 2007
  2. Article first published online: 9 FEB 2007
  3. Manuscript Received: 19 OCT 2006

Funded by

  • Ludwig Translational Research Program
  • NIH/NCI Center for Cancer Nanotechnology Excellence (CCNE)

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Keywords:

  • Kohlenstoffnanoröhren;
  • Nanobiotechnologie;
  • RNA-Interferenz;
  • T-Zellen;
  • Wirkstofftransport

Graphical Abstract

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Sonderlieferung: Funktionalisierte einwandige Nanoröhren (SWNTs) transportieren kurze interferierende RNA (short interfering RNA, siRNA) in humane T-Zellen und Primärzellen und stoppen die Expression HIV-spezifischer Zelloberflächenrezeptoren und -corezeptoren (siehe Bild; Maßstab je 40 μm). Dieser Wirkstoff blockiert das Eindringen von HIV und verringert die Infektion stärker als übliche nichtvirale Transportsysteme auf Liposombasis.

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