Catalytic Asymmetric Synthesis of Tertiary Alkyl Chlorides


  • We thank Michael Choi for preliminary studies and Luke Firmansjah and Dr. Peter Mueller for an X-ray crystallographic investigation. Support has been provided by the NIH (National Institute of General Medical Sciences: R01-GM57034 and F32-GM069154 (fellowship for K.M.M.); National Cancer Institute (training grant CA009112), Merck, and Novartis. Funding for the MIT Department of Chemistry Instrumentation Facility has been furnished in part by NSF CHE-9808061 and NSF DBI-9729592.


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Ketene werden in einer katalytischen asymmetrischen Synthese tertiärer α-Chlorester mit 2,2,6,6-Tetrachlorcyclohexanon gekuppelt (siehe Schema). Diese Methode ergänzt kürzlich bei der Erzeugung sekundärer α-Halogencarbonylverbindungen erzielte Fortschritte.