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A Cell-Permeable Synthetic Transcription Factor Mimic

Authors

  • Xiangshu Xiao Dr.,

    1. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156
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  • Peng Yu Dr.,

    1. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156
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  • Hyun-Suk Lim Dr.,

    1. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156
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  • Devanjan Sikder Dr.,

    1. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156
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  • Thomas Kodadek Prof. Dr.

    1. Division of Translational Research, Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA, Fax: (+1) 214-648-4156
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  • We thank Dr. Bo Liu (UT Southwestern) for providing plasmids and reagents. We also thank Prof. Peter Dervan and Benjamin Edelson (California Institute of Technology) for their gracious assistance and advice regarding the synthesis of hairpin polyamides. This work was supported by grants from the National Institutes of Health (P01-DK58398) and the Welch Foundation (I-1299).

Abstract

original image

Abgespickt? Ein zellgängiges synthetisches Mimetikum für den Transkriptionsfaktor besteht aus einem an DNA bindenden Haarnadel-Polyamid und einem Peptoid, das der Aktivierungsdomäne ähnelt. Dieses Konstrukt kann die Gentranskription in lebenden Zellen einschalten.

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