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All-Carbon Quaternary Stereogenic Centers by Enantioselective Cu-Catalyzed Conjugate Additions Promoted by a Chiral N-Heterocyclic Carbene


  • We are grateful to the NIH (GM-47480) and the NSF (CHE-0213009) for financial support. We thank Professor A. Alexakis (University of Geneva) for generously sharing unpublished results with us (reference [10]). M.K.B. and C.A.B. are recipients of an ACS Graduate Fellowship in Organic Chemistry (sponsored by Schering-Plough) and a Fulbright Distinguished Scholarship, respectively. The X-ray facility at Boston College is supported by Schering-Plough; Dr. R. J. Staples provided valuable assistance in obtaining X-ray structures.


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Not macht erfinderisch: Wenn die verfügbaren Katalysatoren es nicht schaffen, muss ein neuer her – zum Beispiel mit einem chiralen N-heterocyclischen Carben (NHC). Dieser Ligand wurde in der ersten katalytischen asymmetrischen konjugierten Addition von Alkyl- und Arylzinkreagentien an γ-Ketoester eingesetzt.