Development of a T1 Contrast Agent for Magnetic Resonance Imaging Using MnO Nanoparticles

Authors

  • Hyon Bin Na,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
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  • Jung Hee Lee Prof.,

    1. Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea, Fax: (+82) 2-3410-0084
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  • Kwangjin An,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
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  • Yong Il Park,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
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  • Mihyun Park,

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
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  • In Su Lee Prof.,

    1. Department of Chemistry and Advanced Material Science, Kyunghee University, Yongin 446-701, Korea
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  • Do-Hyun Nam Prof.,

    1. Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
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  • Sung Tae Kim Prof.,

    1. Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea, Fax: (+82) 2-3410-0084
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  • Seung-Hoon Kim Prof.,

    1. Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea, Fax: (+82) 2-3410-0084
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  • Sang-Wook Kim Prof.,

    1. Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea
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  • Keun-Ho Lim,

    1. NMR Laboratory, Asan Institutes for Life Science, University of Ulsan, Seoul 138-736, Korea
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  • Ki-Soo Kim Prof.,

    1. Department of Pediatrics, Asan Medical Center, University of Ulsan, Seoul 138-736, Korea
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  • Sun-Ok Kim Dr.,

    1. Biology and Clinical Pharmacology, Samyang R&D Center, Daejeon 305-717, Korea
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  • Taeghwan Hyeon Prof.

    1. National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea, Fax: (+82) 2-886-8457
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  • T.H. thanks the Korean Ministry of Science and Technology for financial support through the National Creative Research Initiative Program of the Korea Science and Engineering Foundation (KOSEF). J.H.L. was supported by the Center for Biological Modulators of the 21st Century Frontier R&D Program. We thank Sungman Jang and Heesouk Woo at the Samsung Medical Center for help in the MRI measurements and TEM studies. We thank Dr. Alan P. Koretsky at NINDS, NIH, and Dr. Seong-Gi Kim at the University of Pittsburgh for useful discussions. T1 refers to the longitudinal relaxation time of water protons.

Abstract

original image

Kontrastreich: Ein T1-Kontrastmittel für die Kernspintomographie (MRI), das auf MnO-Nanopartikeln beruht, bewirkt eine große Signalverstärkung und macht aufgelöste anatomische Strukturen im T1-gewichteten MR-Bild eines Maushirns sichtbar (siehe Bild; links: MRI, rechts: MnO-verstärkte MRI (MONEMRI)). Mit einem tumorspezifischen Antikörper konjugierte MnO-Nanopartikel wurden zudem genutzt, um Brustkrebszellen in einer Metastase im Hirn selektiv abzubilden.

Ancillary