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Enantioselective Organocatalytic Conjugate Addition of N Heterocycles to α,β-Unsaturated Aldehydes

Authors

  • Peter Dinér Dr.,

    1. Danish National Research Foundation: Center for Catalysis Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Martin Nielsen,

    1. Danish National Research Foundation: Center for Catalysis Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Mauro Marigo Dr.,

    1. Danish National Research Foundation: Center for Catalysis Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Karl Anker Jørgensen Prof. Dr.

    1. Danish National Research Foundation: Center for Catalysis Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • This work was made possible by a grant from The Danish National Research Foundation. P.D. thanks the Wenner-Gren Foundation for financial support.

Abstract

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Stickstoff hilft Stickstoff: Chirale Amine katalysieren die enantioselektive Addition von N-heterocyclischen Spezies an α,β-ungesättigte Verbindungen in hohen Ausbeuten und mit Enantioselektivitäten bis 94 % ee (siehe Schema; TMS=Trimethylsilyl). Die Zwischenstufen und Übergangszustände des Katalysezyklus wurden mithilfe von DFT-Rechnungen identifiziert.

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