Tracking the Chiral Recognition of Adsorbed Dipeptides at the Single-Molecule Level

Authors


  • The authors acknowledge Prof. Gero Decher and Dr. Thomas Classen for fruitful discussions and Ignacio Horcas for assistance with WSxM (http://www.nanotec.es), the freeware used to process the STM data. G.T. is grateful to the Garlick Scholarship Foundation for financial support. The work of L.C.C. was supported by the Alexander von Humboldt Stiftung and the Deutsche Forschungsgemeinschaft within the Emmy-Noether Programme, and A.D.V. acknowledges support by the EPSRC (UK) and the ESF EUROCORES SONS Programme. CPU time allocation was provided by the HPCx computing facilities through the UKCP consortium (UK), by the Rechenzentrum Garching facilities (Germany) through the German Max Planck Society, and by the HLRS supercomputing facility (Germany) through the HPC-Europa project (RII3-CT-2003-506079, with the support of the European Community, Research Infrastructure Action of the FP6).

Abstract

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Beleuchtung, Kamera, Aufnahme! Der von Pauling vor mehr als 50 Jahren vorgeschlagene allgemeine Mechanismus der biomolekularen Erkennung wurde nun auf die Leinwand gebracht (siehe Standfoto; D: D-Phe-D-Phe, L: L-Phe-L-Phe). In STM-Filmen wird der Prozess der chiralen Erkennung einzelner adsorbierter Di(phenylalanin)-Moleküle verfolgt, um so den dynamischen Induced-Fit-Mechanismus auf dem Einzelmolekülniveau zu veranschaulichen.

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