Organocatalytic Highly Enantioselective α-Arylation of β-Ketoesters

Authors

  • José Alemán Dr.,

    1. Danish National Research Foundation, Center for Catalysis Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Bo Richter,

    1. Danish National Research Foundation, Center for Catalysis Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Karl Anker Jørgensen Prof. Dr.

    1. Danish National Research Foundation, Center for Catalysis Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • This work was made possible by a grant from the Danish National Research Foundation. J.A. thanks the Ministerio de Educación y Ciencia of Spain for a postdoctoral fellowship. We thank Dr. Jacob Overgaard for performing X-ray analysis, Dr. Kim Frisch for conversations about quinone systems, and Dr. Peter Dinér for help in DFT calculations.

Abstract

original image

Von Chinonen zu komplexen Verbindungen: Die Umsetzung von β-Ketoestern mit Chinonen ermöglicht α-Arylierungen, vor allem wenn der α-Arylring elektronenschiebende Gruppen enthält. Die Reaktion lässt sich enantioselektiv durchführen, wenn Chinaalkaloide als Organokatalysatoren eingesetzt werden, und macht komplexe polycyclische und chirale Spiroverbindungen zugänglich.

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