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Nitroxylcob(III)alamin: Synthesis and X-ray Structural Characterization

Authors

  • Luciana Hannibal,

    1. Department of Chemistry and School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA, Fax: (+1) 330-672-3816
    2. Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
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  • Clyde A. Smith Dr.,

    1. Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, CA 94025, USA
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  • Donald W. Jacobsen Dr.,

    1. Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    2. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
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  • Nicola E. Brasch Dr.

    1. Department of Chemistry and School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA, Fax: (+1) 330-672-3816
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  • This research was funded by Kent State University (N.E.B. and L.H.) and the National Heart Lung and Blood Institute of the National Institutes of Health (HL71907) (D.W.J.).

Abstract

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Geheimnis enthüllt: Eine Kristallstrukturanalyse von Nitrosylcobalamin (NOCbl) ergibt einen Co-N-O-Winkel von 117.4–121.4°. Somit wird NOCbl im festen Zustand am besten als Nitroxylcob(III)alamin beschrieben (siehe Bild: Co violett, N blau, O rot, P orange, C grau, H weiß). Die Länge der Co-N-Bindung in trans-Stellung zum NO-Liganden ist typisch für Systeme mit starken β-axialen Liganden trans zur 5,6-Dimethylbenzimidazol-Einheit.

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