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Asymmetric Organocatalytic α-Arylation of Aldehydes

Authors

  • José Alemán Dr.,

    1. Danish National Research Foundation: Center for Catalysis Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Silvia Cabrera Dr.,

    1. Danish National Research Foundation: Center for Catalysis Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Eddy Maerten Dr.,

    1. Danish National Research Foundation: Center for Catalysis Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Jacob Overgaard Dr.,

    1. Danish National Research Foundation: Center for Catalysis Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • Karl Anker Jørgensen Prof. Dr.

    1. Danish National Research Foundation: Center for Catalysis Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
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  • This work was made possible by a grant from the Danish National Research Foundation. J.A. and S.C. thank the Ministerio de Educación y Ciencia of Spain for a postdoctoral fellowship.

Abstract

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Chinone als Helfer: Die organokatalytische enantioselektive α-Arylierung von Aldehyden mit Chinonen als dem aromatischen Partner verläuft in H2O oder EtOH/H2O-Mischungen sehr effizient. Die optisch aktiven α-arylierten Aldehyde werden in hohen Ausbeuten und mit ausgezeichneten Enantioselektivitäten gebildet (siehe Schema; TMS: Trimethylsilyl).

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